Skip to Content
Press Releases
Prolonged breastfeeding does not protect against eczema, global study shows

The largest worldwide study on the association between breastfeeding, time of weaning and eczema in children has concluded that there is no clear evidence that exclusive breastfeeding for four months or longer protects against childhood eczema, according to research due to be published in the British Journal of Dermatology 24th August 2011.

The researchers, based at King’s College London, The University of Nottingham and the University of Ulm, Germany, looked at data from 51,119 children aged eight to 12, from 21 countries, as part of Phase Two of The International Study of Asthma and Allergies in Childhood (ISAAC)*, the largest epidemiological research project ever undertaken. Their findings have prompted them to call for a review of the current UK breastfeeding guidelines with regard to eczema.

Information on eczema, breastfeeding and time of weaning was gathered by parental questionnaire. Children also underwent a skin examination for eczema and skin prick testing to environmental allergens, including house dust mite.

Earlier studies have suggested a protective effect of breastfeeding on childhood eczema, and the UK Department of Health currently recommends exclusive breastfeeding for six months to prevent eczema, in line with the World Health Organisation. However, a review of the more recent literature found no evidence for a protective effect of exclusive breastfeeding for three months or longer on eczema development1, in keeping with the findings from this study.

The authors also point out that there is mounting evidence to suggest that the early introduction of potentially allergenic food proteins, such as peanut, could increase tolerance to these foods, rather than causing allergy, although this remains to be confirmed in intervention studies.2

This worldwide study therefore sought to investigate to what extent exclusive breastfeeding protects against childhood eczema. It concluded that children who were exclusively breastfed for four months or longer were as likely to develop eczema as children who were weaned earlier.

Dr Carsten Flohr, one of the researchers based at King’s College London, said: “Although there was a small protective effect of breastfeeding per se on severe eczema in affluent countries, we found no evidence that exclusive breastfeeding for four months or longer protects against eczema in either developed or developing nations. We feel that the UK breastfeeding guidelines with regard to eczema should therefore be reviewed. Further studies are now required to explore how and when solids should be introduced alongside breastfeeding to aid protection against eczema and other allergic diseases.”

Dr Flohr is keen to emphasise that other benefits of breastfeeding on infant health, unrelated to eczema, are not being disputed. He explained: “It is widely accepted that breast milk is the most important and appropriate nutrition in early life. Especially in the context of developing countries it is also important to keep in mind that exclusive breastfeeding reduces the risk of gastrointestinal infections compared to mixed or bottle feeding. Our study does not change this notion.”

Nina Goad of the British Association of Dermatologists said: “The size of this study means that its findings are very significant, although the authors recognise that further studies are required. Following these further studies we may need to review the UK’s advice on how long mothers should breastfeed exclusively for, and at what age we should be weaning our infants, in relation to eczema prevention.

“This study isn’t about the benefits of infant formula milk versus breast milk, nor is it questioning other benefits of breast feeding, but it is about whether breastfeeding exclusively for prolonged periods and weaning after six months, as opposed to after four months, has any impact on eczema risk.”

Professor Hywel Williams from The University of Nottingham added: “There is no doubt that breast is best in terms of prevention of infections and parental bonding, but mothers who cannot breastfeed should not feel guilty if their child develops eczema. The evidence that prolonged and exclusive breastfeeding protects against eczema is not convincing.”

Background information

The definitive study design to explore how and when solid foods should be introduced alongside breastfeeding to optimally protect against allergic disease is a randomised controlled trial. Such a trial is currently being conducted at the Children’s Allergies Department at St. Thomas’ Hospital (‘Enquiring About Tolerance’ (EAT) Study;

The Scientific Advisory Committee on Nutrition (SACN) is currently undertaking a review of the scientific evidence underpinning the United Kingdom infant and young child feeding policy, stating that since the Committee on Medical Aspects of Food Policy (COMA) published its report ‘Weaning and the weaning diet’ in 1994, there has not been a thorough risk assessment of such evidence in the UK. (

*ISAAC, The International Study of Asthma and Allergies in Childhood, is a unique worldwide epidemiological research programme established in 1991 to investigate asthma, rhinitis and eczema in children due to considerable concern that these conditions were increasing in western and developing countries. ISAAC has become the largest worldwide collaborative research project ever undertaken, involving more than 100 countries and nearly two million children. Its main aim is to develop environmental measures and disease monitoring in order to form the basis for future interventions to reduce the burden of allergic diseases, especially in children in developing countries.


1 •Yang YW, Tsai CL, Lu CY. Exclusive breastfeeding and incident atopic dermatitis in childhood: a systematic review and meta-analysis of prospective cohort studies. Br J Dermatol 2009;161:373-83. • Fewtrell M, Wilson DC, Booth I, Lucas A. Six months of exclusive breastfeeding: how good is the evidence? Brit Med J 2011; 342: 209-12. • Department of Health. Weaning and the Weaning Diet. Report of the Working Group on the Weaning Diet of the Committee on Medical Aspects of Food Policy. Report on Health and Social Subjects No 45. 1994 HMSO, London. • Burr ML, Butland BK, King S, Vaughan-Williams E. Changes in asthma prevalence: two surveys 15 years apart. Arch Dis Child 1989;64:1452-6. 2 • Burks AW, Laubach S, Jones SM. Oral tolerance, food allergy, and immunotherapy: implications for future treatment. J Allergy Clin Immunol 2008;121:1344-50. • Du Toit G, Katz Y, Sasieni P, et al. Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J Allergy Clin Immunol 2008;122:984-91.

Notes to editors:

1. The information in this press release is embargoed until 00:01 on 24th August 2011. If using this information, please ensure you mention that the study is being released in the British Journal of Dermatology, the official publication of the British Association of Dermatologists

2. For more information please contact: Deborah Mason, British Association of Dermatologists, Phone: 0207 391 6355, Email:, Website:

3. Articles in the BJD can be viewed online: British Journal of Dermatology: Lack of evidence for a protective effect of prolonged breastfeeding on childhood eczema: Lessons from the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two; C. Flohr1, G. Nagel2, G. Weinmayr2, A. Kleiner2, D.P. Strachan3, Hywel C. Williams4, and the ISAAC Phase Two Study Group. 1Department of Paediatric Allergy & Dermatology, St John’s Institute of Dermatology, St Thomas’ Hospital and King’s College London, UK; 2 Institute of Epidemiology, University of Ulm, Germany; 3Division of Community Health Sciences, St. George’s, University of London, United Kingdom; 4 Centre for Evidence Based Dermatology, University of Nottingham, UK.

• The British Association of Dermatologists is the central association of practising UK dermatologists. Our aim is to continually improve the treatment and understanding of skin disease.

• Wiley-Blackwell, created in February 2007 by merging Blackwell Publishing with Wiley's Global Scientific, Technical, and Medical business, is now one of the world's foremost academic and professional publishers and the largest society publisher. With a combined list of more than 1,400 scholarly peer-reviewed journals and an extensive collection of books with global appeal, this new business sets the standard for publishing in the life and physical sciences, medicine and allied health, engineering, humanities and social sciences. For more information visit

• The University of Nottingham, described by The Sunday Times University Guide 2011 as ‘the embodiment of the modern international university’, has award-winning campuses in the United Kingdom, China and Malaysia. It is ranked in the UK's Top 10 and the World's Top 75 universities by the Shanghai Jiao Tong (SJTU) and the QS World University Rankings.

• King's College London is one of the top 25 universities in the world (2010 QS international world rankings), The Sunday Times 'University of the Year 2010/11' and the fourth oldest in England. King's has an outstanding reputation for providing world-class teaching and cutting-edge research. It is the largest centre for the education of healthcare professionals in Europe; no university has more Medical Research Council Centres.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts. 

Back to top