You can download this leaflet by clicking here

Patient Information Leaflet

Bowen's Disease

What are the aims of this leaflet?

This leaflet has been written to help you understand more about Bowen’s disease. It tells you what it is, what causes it, what can be done about it, and where you can find out more about it.

What is Bowen’s disease?

Bowen’s disease is also known as intraepidermal squamous cell carcinoma, and is a growth of cancerous cells that is confined to the outer layer of the skin. It is not a serious condition, and its importance rests on the fact that, occasionally, it can progress into an invasive skin cancer (squamous cell carcinoma). For this reason, dermatologists usually treat, or at least keep an eye on, Bowen's disease.

What causes Bowen’s disease?

Most cases of Bowen’s disease develop as a result of long-term sun exposure. Very occasionally, Bowen’s disease may be seen in the context of previous radiotherapy, following chronic arsenic ingestion (very rare nowadays) or on the genitalia in association with the virus that causes warts (the human papillomavirus). Bowen's disease is neither infectious, nor due to an allergy.

Is it hereditary?

No, it is not; but some of the factors that increase the risk of getting it, such as a fair skin and a tendency to burn in the sun, do run in families.

What are its symptoms?

Often there are no symptoms, although the surface crusting may catch on clothing.

What does it look like?

A patch of Bowen’s disease starts as a small red scaly area, which grows very slowly. It may reach a diameter of a few centimetres across. It commonly occurs on sun-exposed skin, especially the head, hands and lower legs. More than one lesion may be present. The development of an ulcer or lump on a patch of Bowen’s disease may indicate the formation of invasive squamous cell carcinoma.

How will it be diagnosed?

A patch of Bowen’s disease can look rather like other skin conditions, such as psoriasis. For this reason a biopsy may be needed to make the diagnosis.

Can it be cured?

Yes. As Bowen’s disease is confined to the surface of the skin, there are a variety of ways in which this can be achieved (see below).

How can it be treated?

 A number of treatments are available for Bowen’s disease:

• Freezing with liquid nitrogen. This is done in the clinic. It causes redness, puffiness, blistering or crusting, and may be slow to heal. It can be done in stages for large areas of Bowen's disease.
  
• Curettage. This involves scraping off the abnormal skin under a local anaesthetic. The area then heals with a scab, like a graze.
  
• Excision. The abnormal skin can be cut out, under local anaesthetic, provided it is not too large. Usually it involves stitching the skin.
  
• 5-fluorouracil (Efudix) cream. This is a cream that may control or eradicate the disorder. There are various different ways of using it, and, if it is felt to be the best treatment, the doctor who sees you will explain these to you. Efudix works by killing the abnormal skin cells. This means that the skin will become red and look worse during treatment, and will then heal after the end of the course of treatment, once the abnormal cells have gone.
  
• Imiquimod cream. This was originally developed for the treatment of genital warts, but imiquimod cream has been found useful in treating Bowen’s disease. It also causes inflammation of the skin during treatment.
  
• Photodynamic therapy. A chemical is applied to the skin that makes the cells in the patch of Bowen’s disease sensitive to particular wavelengths of light. Light from a special lamp is then shone on the lesion. The treatment can be associated with pain and inflammation.
  

However, a particular problem is that Bowen’s disease is frequently found on the lower leg - where the skin is often tight and sometimes quite fragile, especially in older patients. Healing there is slow. Many factors, therefore, play a part in selecting the right treatment:

• The size and thickness of the patch
  
• The number of patches
  
• The presence of swelling of the legs
  
• The general state of the skin on the legs
  

If your patch is judged to be thin and not troublesome, your dermatologist may simply suggest that it is kept under observation in a clinic, or in some cases by yourself or by your GP.

What can I do?

• From now on, you should take sensible precautions to stop another patch of Bowen’s disease coming up. This means wearing clothing that protects you against the sun, avoiding strong sunlight, and using a sun block with a sun protection factor (SPF) of at least 30.
  
• Check your skin regularly for new lesions.
  
• The smaller your patch of Bowen’s disease is, the better the results of treatment are likely to be. If you think another one is coming up, see your doctor about it early rather than late.
  
• If your patch changes in any way (bleeds, ulcerates or develops a lump) contact your doctor quickly as this could be the start of an invasive skin cancer.
  

Where can I get more information?

Web link to detailed leaflet:

www.emedicine.com/derm/topic59.htm
www.dermnetnz.org/lesions/bowen.html

The British Skin Foundation fund vital research into all skin diseases.  To find out how you can help, please visit the British Skin Foundation website here.

This leaflet aims to provide accurate information about the subject and is a consensus of the views held by representatives of the British Association of Dermatologists: its contents, however, may occasionally differ from the advice given to you by your doctor.

BRITISH ASSOCIATION OF DERMATOLOGISTS
PATIENT INFORMATION LEAFLET
PRODUCED JUNE 2007
UPDATED MAY 2010